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Multifunctional silica nanoparticles for optical and magnetic resonance imaging

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83996

Joshi,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83941

Feldmann V, Koestner W, Detje C, Gottschalk,  S
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83903

Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Joshi, R., Feldmann V, Koestner W, Detje C, Gottschalk, S., Mayer HA, Sauer, M., & Engelmann, J. (2013). Multifunctional silica nanoparticles for optical and magnetic resonance imaging. Biological Chemistry, 394(1), 125–135. Retrieved from http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfeventlink/002fj002fbchm.2013.394.issue-1002fhsz-2012-0251002fhsz-2012-0251.xml?t:ac=j002fbchm.2013.394.issue-1002fhsz-2012-0251002fhsz-2012-0251.xml.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-B51E-F
Abstract
The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9–16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×105 and ~5×105 /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.