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A common fungal associate of the spruce bark beetle metabolizes the stilbene defenses of Norway spruce


Brand,  Willi A.
Service Facility Stable Isotope, Dr. W. A. Brand, Max Planck Institute for Biogeochemistry, Max Planck Society;

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Hammerbacher, A., Schmidt, A., Wadke, N., Wadke, L., Schneider, B., Bohlmann, J., et al. (2013). A common fungal associate of the spruce bark beetle metabolizes the stilbene defenses of Norway spruce. Plant Physiology, 162, 1324-1336. doi:10.1104/pp.113.218610.

Norway spruce (Picea abies) forests suffer periodic fatal attacks by the bark beetle Ips typographus and its fungal associate, Ceratocystis polonica. P. abies protects itself against fungal and bark beetle invasion by production of terpenoid resins, but it is unclear whether resins or other defenses are effective against the fungus. We investigated stilbenes, a group of phenolic compounds found in P. abies bark with a diaryl-ethene skeleton with known antifungal properties. During C. polonica infection, stilbene biosynthesis was up-regulated as evidenced by elevated transcript levels of stilbene synthase genes. However, stilbene concentrations actually declined during infection and this was due to fungal metabolism. C. polonica converted stilbenes to ring-opened, deglycosylated and dimeric products. Chromatographic separation of C. polonica protein extracts confirmed that these metabolites arose from specific fungal enzyme activities. Comparison of C. polonica strains showed that rapid conversion of host phenolics is associated with higher virulence. C. polonica is so well adapted to its host’s chemical defenses that it is even able to use host phenolic compounds as its sole carbon source.