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Combinatorial complexity of pathway analysis in metabolic networks

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86189

Klamt,  S.
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86232

Stelling,  J.
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Zitation

Klamt, S., & Stelling, J. (2002). Combinatorial complexity of pathway analysis in metabolic networks. Molecular Biology Reports, 29(1-2), 233-236. doi:10.1023/A:1020390132244.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-A0BF-8
Zusammenfassung
Elementary flux mode analysis is a promising approach for a pathway-oriented perspective of metabolic networks. However, in larger networks it is hampered by the combinatorial explosion of possible routes. In this work we give some estimations on the combinatorial complexity including theoretical upper bounds for the number of elementary flux modes in a network of a given size. In a case study, we computed the elementary modes in the central metabolism of Escherichia coli while utilizing four different substrates. Interestingly, although the number of modes occurring in this complex network can exceed half a million, it is still far below the upper bound. Hence, to a certain extent, pathway analysis of central catabolism is feasible to assess network properties such as flexibility and functionality. © Copyright 2008 Elsevier B.V., All rights reserved. [accessed 2013 June 13th]