Analysis of the isolation of a target component using multicomponent isocratic 
preparative elution chromatography

Shan, Y.; Seidel-Morgenstern, A.

doi:10.1016/j.chroma.2004.04.061

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Analysis of the isolation of a target component using multicomponent isocratic preparative elution chromatography

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Shan, Y.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Seidel-Morgenstern, A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Shan, Y., & Seidel-Morgenstern, A. (2004). Analysis of the isolation of a target component using multicomponent isocratic preparative elution chromatography. Journal of Chromatography A, 1041, 53-62. doi:10.1016/j.chroma.2004.04.061.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-9E7F-9

Abstract

The separation of a certain target component from a multicomponent mixture using isocratic preparative elution chromatography was studied theoretically. In particular, the important and most complicated case was considered that the target component does not elute in the first or last position. To specify the productivity of collecting this component different options are suggested to identify suitable times for fractionation. Using a conventional Craig model, capable to quantify chromatographic processes, the impact of several essential parameters (e.g. threshold concentration, desired purity, injection volume, separation factor between neighboring components, composition of the mixture) is evaluated for a ternary system based on parametric calculations. The paper provides simple tools to evaluate and optimize the productivity and other objective functions relevant in multicomponent preparative chromatography. © 2003 Elsevier B.V. All rights reserved. [accessed 2013 November 27th]