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Shortcut Method for Evaluation and Design of a Hybrid Process for Enantioseparations

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86349

Kaspereit,  M.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86301

Gedicke,  K.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86525

Zahn,  V.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86393

Mahoney,  A. W.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86477

Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Kaspereit, M., Gedicke, K., Zahn, V., Mahoney, A. W., & Seidel-Morgenstern, A. (2005). Shortcut Method for Evaluation and Design of a Hybrid Process for Enantioseparations. Journal of Chromatography A, 1092(1), 43-54. doi:10.1016/j.chroma.2005.02.043.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-9CE9-D
Abstract
Hybrid processes for enantioseparations have a considerable potential for reducing investment and operational costs. An example is the combination of simulated moving bed (SMB) chromatography and selective crystallisation. However, the design of integrated processes is a difficult task. A shortcut method is presented that can serve as a tool for design and estimation of the potential of such processes. The approach requires only limited experimental data and thus allows for systematic parameters studies. The method is based on the determination of the purity-performance characteristic of the SMB process and rigorous application of mass balances. The use of relative mass fluxes allows derivation of simple algebraic expressions for essential process parameters. The significant potential of combining SMB and crystallisation is demonstrated for the example of the separation of mandelic acid enantiomers. © 2005 Elsevier B.V. All rights reserved. [accessed 2013 November 27th]