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Using Chemical Reaction Network Theory to discard a Kinetic Mechanism Hypothesis

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons86220

Saez-Rodriguez,  Julio
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86172

Gilles,  Ernst Dieter
Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86212

Raisch,  Jörg
Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Conradi, C., Saez-Rodriguez, J., Gilles, E. D., & Raisch, J. (2005). Using Chemical Reaction Network Theory to discard a Kinetic Mechanism Hypothesis. IEE Proceedings Systems Biology, 152(4), 243-248. doi:10.1049/ip-syb:20050045.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-9B6E-9
Abstract
Feinberg’s Chemical Reaction Network Theory (CRNT) connects the structure of a biochemical reaction network to qualitative properties of the corresponding system of ordinary differential equations. In particular, no information about parameter values is needed. As such, it seems to be well suited for application in systems biology, where parameter uncertainty is predominant. However, its application in this area is rare, at best. To demonstrate potential benefits from the application, different reaction networks representing a single layer of the well studied Mitogen-activated protein kinase (MAPK) cascade are analyzed. Recent results from Markevich et al. (2004) show that, unexpectedly, multilayered protein kinase cascades can exhibit multistationarity even on a single cascade level. Using CRNT, we show that their assumption of a distributive mechanism for double phosphorylation and dephosphorylation is crucial for multistationarity on the single cascade level. © Copyright 2013 IEEE - All rights reserved [accessed 2013 June 13th]