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Characterization and analytical issues on an influenza A virus production process

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86303

Genzel,  Y.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86343

Kalbfuss,  B.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86451

Ritter,  J. B.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86473

Schulze-Horsel,  J.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86442

Rapp,  E.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86508

Vester,  D.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86448

Reichl,  U.
Otto-von-Guericke-Universität Magdeburg;
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Citation

Genzel, Y., Kalbfuss, B., Ritter, J. B., Schulze-Horsel, J., Rapp, E., Vester, D., et al. (2006). Characterization and analytical issues on an influenza A virus production process. Talk presented at Vaccines: Quality control, scale-up and manufacture. Hamburg, Germany. 2006-12-05 - 2006-12-06.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-9961-6
Abstract
Different approaches for a mammalian cell culture based production process for influenza vaccines are currently in development. Each approach needs optimization based on analytical data collected from many small scale experiments. In the presentation results for different cultivation methods (rollerbottles, stirred tank or wave bioreactor microcarrier system) for a production process with adherent MDCK cells are discussed. Analytical data on cell numbers, metabolism, host cell protein level, cell cycle and virus titer are shown.