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Vaccine production - state of the art and future needs in upstream processing

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86303

Genzel,  Y.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86448

Reichl,  U.
Otto-von-Guericke-Universität Magdeburg;
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Citation

Genzel, Y., & Reichl, U. (2007). Vaccine production - state of the art and future needs in upstream processing. In R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols (pp. 457-473). Totowa, New Jersey: HUMANA Press Inc.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-98E9-B
Abstract
The production of viral vaccines in animal cell culture can be accomplished with primary, diploid or continuous (transformed) cell lines. Each cell line, each virus type and each vaccine definition requires a specific production and purification process. Media have to be selected as well as the production vessel, production conditions and the type of process. Here, we describe different issues that have to be considered during virus production processes by discussing the influenza virus production in a microcarrier system in detail as an example. The use of serum-containing as well as serum-free media, but also the use of stirred tank bioreactors or wave bioreactors is considered. Copyright © 2008 Springer Science+Business Media, LLC. All rights reserved [accessed 2013 October 29th]