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Design of simulated moving bed processes under reduced purity requirements

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86349

Kaspereit,  M.
Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86477

Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86359

Kienle,  A.
Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Kaspereit, M., Seidel-Morgenstern, A., & Kienle, A. (2007). Design of simulated moving bed processes under reduced purity requirements. Journal of Chromatography A, 1162, 2-13. doi:10.1016/j.chroma.2007.02.063.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-98C4-E
Abstract
The design of simulated moving bed chromatography under limited purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory. Copyright © 2007 Elsevier Ltd. All rights reserved. [accessed 2013 November 26th]