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Conceptual design & feasibility study of combining continuous chromatography and crystallization for stereoisomer separations

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons86301

Gedicke,  K.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86349

Kaspereit,  Malte
Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86390

Lorenz,  H.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86477

Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Gedicke, K., Kaspereit, M., Beckmann, W., Budde, U., Lorenz, H., & Seidel-Morgenstern, A. (2007). Conceptual design & feasibility study of combining continuous chromatography and crystallization for stereoisomer separations. Chemical Engineering Research and Design, 85(7), 928-936. doi:10.1205/cherd06224.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-98B8-A
Abstract
The separation of stereoisomers - diastereoisomers and enantiomers - constitutes an important class of problems in life science applications, namely in drug manufacture. Chromatography is often the method of choice to perform this task. To decrease the typically high investment and operational costs of the chromatographic separation, it can be beneficial to combine this process with a selective crystallisation step. This work investigates such process combination of Simulated Moving Bed chromatography and crystallisation from solution. A short-cut method, based on only a few fundamental experimental parameters, is applied to evaluate the process combination for one enantiomeric and one epimeric system. While the enantiomeric system is characterised by a simple conglomerate phase diagram, the epimeric system shows some characteristic properties, like incorporation of the counter epimer and an additional impurity into the crystal lattice of the product epimer, that have to be accounted for by more detailed investigations. Copyright © 2007 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. [accessed February 8th 2013]