A Method to evaluate the feasibility of TMB chromatography for reduced 
efficiency and purity requirements based on discrete optimization

Haus, U.-U.; Michaels, D.; Seidel-Morgenstern, A.; Weismantel, R.

doi:10.1016/j.compchemeng.2007.01.001

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A Method to evaluate the feasibility of TMB chromatography for reduced efficiency and purity requirements based on discrete optimization

MPG-Autoren

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Seidel-Morgenstern, A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Haus, U.-U., Michaels, D., Seidel-Morgenstern, A., & Weismantel, R. (2007). A Method to evaluate the feasibility of TMB chromatography for reduced efficiency and purity requirements based on discrete optimization. Computers and Chemical Engineering, 31(11), 1525-1534. doi:10.1016/j.compchemeng.2007.01.001.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-9888-7

Zusammenfassung

This paper introduces an exact mathematical approach based on combinatorial optimization to analyze continuous linear countercurrent chromatographic processes. The analysis is based on a given set of input parameters including, in particular, purity requirements and number of plates per zone. As an outcome of the analysis either a proof of infeasibility is derived for a given set of parameters, or a feasible solution is found that is in correspondence with the input requirements. Details regarding the mathematical combinatorial subproblems are presented. Copyright © 2013 Elsevier B.V. [accessed 2013 November 26th]