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Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86303

Genzel,  Y.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons101695

Fischer,  Marlies
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Universität Stuttgart, Lehrstuhl für Bioverfahrenstechnik, Stuttgart, Germany ;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86421

Olmer,  R. M.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Universität Bielefeld, Lehrstuhl für Zellkulturtechnik;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86464

Schäfer,  B.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86371

König,  S.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86332

Hundt,  B.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86448

Reichl,  U.
Otto-von-Guericke-Universität Magdeburg;
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Zitation

Genzel, Y., Fischer, M., Olmer, R. M., Schäfer, B., Best, C., König, S., et al. (2007). Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor. In R. Smith (Ed.), Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting (pp. 563-565). Dordrecht, The Netherlands: Springer.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-986D-5
Zusammenfassung
A serum-free process for influenza virus vaccine production (equine and human) in roller bottles and microcarrier systems in 5L-stirred tank and 2L-wave bioreactor (Cytodex 1) is described. MDCK cells were adapted from growth in serum containing GMEM medium to serum-free Ex-Cell MDCK medium. Virus titers of 2.0-2.9 log HA units/ 100 µL were obtained. Omission of the medium exchange before infection has clearly simplified the process. © Springer, Part of Springer Science+Business Media [accessed 2013 September 9th]