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Closed loop control of perfusion systems in high-density cell culture

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86258

Bock,  A.
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86448

Reichl,  U.
Otto-von-Guericke-Universität Magdeburg;
Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Zitation

Bock, A., & Reichl, U. (2007). Closed loop control of perfusion systems in high-density cell culture. In R. Smith (Ed.), Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting (pp. 549-551). Dordrecht, The Netherlands: Springer.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-9869-D
Zusammenfassung
The use of a perfusion system prevented unspecific inhibitions effects on cell growth for batch cultivations of adherent MDCK cells used for an equine influenza A vaccine production process. It also increased viable cell numbers. An enzyme sensor for monitoring and closed loop control of metabolites operated stable for at least 55 hours.