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Journal Article

#### Computing knock-out strategies in metabolic networks

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##### Citation

Haus, U.-U., Klamt, S., & Stephen, T. (2008). Computing knock-out strategies in
metabolic networks.* Journal of Computational Biology,* *15*(3),
259-268. doi:10.1089/cmb.2007.0229.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-9637-B

##### Abstract

Given a metabolic network in terms of its metabolites and reactions, our goal is to efficiently compute the minimal knock-out sets of reactions required to block a given behavior. We describe an algorithm that improves the computation of these knock-out sets when the elementary modes (minimal functional subsystems) of the network are given. We also describe an algorithm that computes both the knock-out sets and the elementary modes containing the blocked reactions directly from the description of the network and whose worst-case computational complexity is better than the algorithms currently in use for these problems. Computational results are included.
Copyright © Mary Ann Liebert, Inc.
[accessed July 1, 2008]