Optimization of simulated moving bed chromatography with fractionation and 
feedback: Part I. Fractionation of one outlet

Li, S.; Kawajiri, Y.; Raisch, J.; Seidel-Morgenstern, A.

doi:10.1016/j.chroma.2010.06.031

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Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet

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Li, S.
Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

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Raisch, J.
Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
TU Berlin;

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Seidel-Morgenstern, A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Li, S., Kawajiri, Y., Raisch, J., & Seidel-Morgenstern, A. (2010). Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet. Journal of Chromatography A, 1217(33), 5337-5348. doi:10.1016/j.chroma.2010.06.031.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-90A1-7

Abstract

A novel modification of simulated moving bed (SMB) technology, referred to as fractionation and feedback SMB (FF-SMB), has been introduced recently. This concept is based on fractionating one or both outlet streams and feeding the off-spec fractions back into the unit alternatingly with the original feed mixture. In this paper, the optimization problem of FF-SMB realizing one outlet fractionation is considered. A mathematical optimization framework based on a detailed process model is presented which allows to evaluate quantitatively the potential of this operating scheme. Detailed optimization studies have been carried out for a difficult separation characterized by small selectivity and low column efficiency. The results reveal that the proposed fractionation and feedback regime can be significantly superior to the classical SMB chromatography, in terms of both feed throughput and desorbent consumption. The effect of the feeding sequence on the performance of FF-SMB is also examined. © 2010 Elsevier B.V. All rights reserved. [accessed September 20th, 2010]