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Optimization of startup and shutdown operation of simulated moving bed chromatographic processes

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons86199

Li,  S.
Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86212

Raisch,  J.
Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
TU Berlin;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons86477

Seidel-Morgenstern,  A.
Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society;
Otto-von-Guericke-Universität Magdeburg, External Organizations;

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Citation

Li, S., Kawajiri, Y., Raisch, J., & Seidel-Morgenstern, A. (2011). Optimization of startup and shutdown operation of simulated moving bed chromatographic processes. Journal of Chromatography A, 1218(25), 3876-3889. doi:10.1016/j.chroma.2011.04.051.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-8D28-7
Abstract
This paper presents new multistage optimal startup and shutdown strategies for simulated moving bed (SMB) chromatographic processes. The proposed concept allows to adjust transient operating conditions stage-wise, and provides capability to improve transient performance and to fulfill product quality specifications simultaneously. A specially tailored decomposition algorithm is developed to ensure computational tractability of the resulting dynamic optimization problems. By examining the transient operation of a literature separation example characterized by nonlinear competitive isotherm, the feasibility of the solution approach is demonstrated, and the performance of the conventional and multistage optimal transient regimes is evaluated systematically. The quantitative results clearly show that the optimal operating policies not only allow to significantly reduce both duration of the transient operation phase and desorbent consumption, but also enable on-spec production even during startup and shutdown periods. With the aid of the developed transient procedures, short-term separation campaigns with small batch sizes can be performed more flexibly and efficiently by SMB chromatography. Copyright © 2011 Published by Elsevier B.V. [accessed May 27th 2011]