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Journal Article

OCT4 and the acquisition of oocyte developmental competence during folliculogenesis

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50471

Prigione,  A.
Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50054

Adjaye,  J.
Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;
Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heiner University;

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Zuccotti.pdf
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Citation

Zuccotti, M., Merico, V., Belli, M., Mulas, F., Sacchi, L., Zupan, B., et al. (2012). OCT4 and the acquisition of oocyte developmental competence during folliculogenesis. International Journal of Developmental Biology, 56(10-11-12), 853-858. doi:10.1387/ijdb.120174mz.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-F0BF-0
Abstract
The role that the transcription factor OCT4 plays during oocyte growth is yet unknown. In this review, we summarise the data on its potential role in the acquisition of oocyte developmental competence in the mouse. These studies describe the presence in MII oocytes and 2-cell embryos of an OCT4 transcriptional network that might be part of the molecular signature of maternal origin on which the inner cell mass and the embryonic stem cell-associated pluripotency is assembled and shaped. The Oct4-gene regulatory network thus provides a connection between eggs, early preimplantation embryos and embryonic stem cells.