Activation of Imd pathway in hemocyte confers infection resistance through 
humoral response in Drosophila

Nelson, Bryce; Freisinger, Tina; Ishii, Kenichi; Okado, Kiyoshi; Shinzawa, Naoaki; Fukumoto, Shinya; Kanuka, Hirotaka

doi:10.1016/j.bbrc.2012.12.027

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Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila

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Freisinger, Tina
Wedlich-Söldner, Roland / Cellular Dynamics and Cell Patterning, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Nelson, B., Freisinger, T., Ishii, K., Okado, K., Shinzawa, N., Fukumoto, S., et al. (2013). Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(3), 1120-1125. doi:10.1016/j.bbrc.2012.12.027.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-DFA0-F

Abstract

Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria. (C) 2012 Elsevier Inc. All rights reserved.