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Abstract

Novel Vaccination Strategies offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title. Contents PART I Preface Introduction: Challenges for the vaccine developer, including correlates of protection PART II VACCINATION AND IMMUNE RESPONSE Shaping adaptive immunity against pathogens: the contribution of innate immune responses Adjuvant induced Th2 and Th1 dominated immune responses in vaccination Memory T-cell based vaccines PART III ADJUVANTS Microbial adjuvants Host derived adjuvants Microparticles as vaccine adjuvants and delivery systems Liposomes and ISCOMs Virosomal technology and mucosal adjuvants PART IV CLASSICAL AND NOVEL VACCINATION STRATEGIES: A COMPARISON Classical bacterial vaccines Subunit vaccines and toxoids Engineering virus vectors for subunit vaccines Update on antiviral DNA vaccine research (2000-2003) Live recombinant bacterial vaccines Mucosal vaccination Passive vaccination and antidotes: A novel strategy for generation of wide-spectrum protective antibodies Plant-based oral vaccines Virus-like particles: Combining innate and adaptive immunity for effective vaccination PART V VACCINES FOR SPECIFIC TARGETS Helicobacter pylori Tuberculosis: Novel vaccination strategies against tuberculosis Rationale for malaria vaccine development HIV Vaccines against bioterror agents Part VI VACCINES IN THE REAL WORLD: SAFETY, COST-EFFICIENCY AND IMPACT OF VACCINATION Imperfect vaccines and the evolution of pathogen virulence Cost-effectiveness of vaccinations Immunological safety of vaccines: facts, hypothesis and allegations