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Identification of regulatory RNAs in Bacillus subtilis

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons82158

Sharma,  Cynthia Mira
Max-Planck Research Group RNA Biology, Max Planck Institute for Infection Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons82198

Vogel,  Jörg
Max-Planck Research Group RNA Biology, Max Planck Institute for Infection Biology, Max Planck Society;

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Volltexte (frei zugänglich)

Nucl_Acids_Res_2010_38_6637.pdf
(Verlagsversion), 872KB

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Zitation

Irnov, I., Sharma, C. M., Vogel, J., & Winkler, W. C. (2010). Identification of regulatory RNAs in Bacillus subtilis. Nucleic Acids Research, 38(19), 6637-6651.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000E-BF8C-6
Zusammenfassung
Post-transcriptional regulatory mechanisms are widespread in bacteria. Interestingly, current published data hint that some of these mechanisms may be non-random with respect to their phylogenetic distribution. Although small, trans-acting regulatory RNAs commonly occur in bacterial genomes, they have been better characterized in Gram-negative bacteria, leaving the impression that they may be less important for Firmicutes. It has been presumed that Gram-positive bacteria, in particular the Firmicutes, are likely to utilize cis-acting regulatory RNAs located within the 5' mRNA leader region more often than trans-acting regulatory RNAs. In this analysis we catalog, by a deep sequencing-based approach, both classes of regulatory RNA candidates for Bacillus subtilis, the model microorganism for Firmicutes. We successfully recover most of the known small RNA regulators while also identifying a greater number of new candidate RNAs. We anticipate these data to be a broadly useful resource for analysis of post-transcriptional regulatory strategies in B. subtilis and other Firmicutes.