English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

MPS-Authors
/persons/resource/persons82154

Seiler,  Katharina
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

/persons/resource/persons82188

Tsuneto,  Motokazu
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

/persons/resource/persons82041

Melchers,  Fritz
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

J_Biomed_Biotechnol_2011_895086.pdf
(Publisher version), 524KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Seiler, K., Tsuneto, M., & Melchers, F. (2011). Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation. Journal of Biomedicine and Biotechnology, 895086. doi:10.1155/2011/895086.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-BF3C-B
Abstract
We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations.