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Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons82154

Seiler,  Katharina
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons82188

Tsuneto,  Motokazu
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons82041

Melchers,  Fritz
Max-Planck Fellowship Lymphocyte Development, Max Planck Institute for Infection Biology, Max Planck Society;

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J_Biomed_Biotechnol_2011_895086.pdf
(Verlagsversion), 524KB

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Zitation

Seiler, K., Tsuneto, M., & Melchers, F. (2011). Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation. Journal of Biomedicine and Biotechnology, 895086. doi:10.1155/2011/895086.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000E-BF3C-B
Zusammenfassung
We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations.