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Journal Article

Functional Specialization of Parallel Motion Detection Circuits in the Fly

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons38912

Joesch,  Maximilian
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons39108

Weber,  Franz
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38813

Eichner,  Hubert
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38770

Borst,  Alexander
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

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Citation

Joesch, M., Weber, F., Eichner, H., & Borst, A. (2013). Functional Specialization of Parallel Motion Detection Circuits in the Fly. JOURNAL OF NEUROSCIENCE, 33(3), 902-905. doi:10.1523/JNEUROSCI.3374-12.2013.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-B644-C
Abstract
In the fly Drosophila melanogaster, photoreceptor input to motion vision is split into two parallel pathways as represented by first-order interneurons L1 and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways are functionally specialized remains controversial. One study (Eichner et al., 2011) proposed that the L1-pathway evaluates only sequences of brightness increments (ON-ON), while the L2-pathway processes exclusively brightness decrements (OFF-OFF). Another study (Clark et al., 2011) proposed that each of the two pathways evaluates both ON-ON and OFF-OFF sequences. To decide between these alternatives, we recorded from motion-sensitive neurons in flies in which the output from either L1 or L2 was genetically blocked. We found that blocking L1 abolishes ON-ON responses but leaves OFF-OFF responses intact. The opposite was true, when the output from L2 was blocked. We conclude that the L1 and L2 pathways are functionally specialized to detect ON-ON and OFF-OFF sequences, respectively.