Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi 
network

von Blume, Julia; Alleaume, Anne-Marie; Kienzle, Christine; Carreras-Sureda, Amado; Valverde, Miguel; Malhotra, Vivek

doi:10.1083/jcb.201207180

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Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network

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von Blume, Julia
von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society;

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Kienzle, Christine
von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

von Blume, J., Alleaume, A.-M., Kienzle, C., Carreras-Sureda, A., Valverde, M., & Malhotra, V. (2012). Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network. JOURNAL OF CELL BIOLOGY, 199(7), 1057-1066. doi:10.1083/jcb.201207180.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-AC28-A

Abstract

Ca2+ import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca2+ retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca2+ import into the TGN; it binds secretory cargo in a Ca2+-dependent reaction and is required for its sorting at the TGN.