de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Chronic calcium imaging in neuronal development and disease

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons38748

Aramuni,  Gayane
Research Group: Cellular Dynamics / Griesbeck, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38863

Griesbeck,  Oliver
Research Group: Cellular Dynamics / Griesbeck, MPI of Neurobiology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Aramuni, G., & Griesbeck, O. (2013). Chronic calcium imaging in neuronal development and disease. Experimental Neurology, 242, 50-56. doi:10.1016/j.expneurol.2012.02.008.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-AB61-0
Abstract
Neuronal circuits develop, adjust to experience and degenerate in response to injury or disease in the course of weeks and months. Available recording techniques, however, typically sample physiological properties of identified neurons on the time scale of minutes and hours. Thus, in order to obtain a full understanding of a long term physiological process data need to be extrapolated from numerous experimental sessions and animals, often collected blindly and under variable conditions. The generation and ongoing engineering of genetically encoded calcium indicators creates an opportunity to repeatedly record activity from the same individual neurons in vivo over weeks, months and potentially the entire lifetime of a model organism. Chronic calcium imaging with genetically encoded indicators thus may allow to establish functional biographies of identified neuronal cell types in the brain and to reveal the physiological relevance of structural changes as they occur under natural and pathological conditions.