de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men

MPG-Autoren

Kellner,  M
Max Planck Institute of Psychiatry, Max Planck Society;

Yassouridis,  A
Max Planck Institute of Psychiatry, Max Planck Society;

Hua,  Y
Max Planck Institute of Psychiatry, Max Planck Society;

Wendrich,  M
Max Planck Institute of Psychiatry, Max Planck Society;

Jahn,  H
Max Planck Institute of Psychiatry, Max Planck Society;

Wiedemann,  K
Max Planck Institute of Psychiatry, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Kellner, M., Yassouridis, A., Hua, Y., Wendrich, M., Jahn, H., & Wiedemann, K. (2002). Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men. Journal of Psychiatric Research, 36(1), 1-6.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000E-A267-0
Zusammenfassung
Given the anxiogenic effects of the type-B natriuretic peptide receptor agonist C-type natriuretic peptide (CNP) in rodents. we investigated the influence of CNP pretreatment upon the behavioral and endocrine action of the panicogen cholecystokinin tetrapeptide (CCK-4) in healthy men. In a randomized double-blind balanced design, 20 male volunteers were given an intravenous infusion of 300 mug of CNP vs. placebo followed by 25 mug of CCK-4. The behavior was assessed using panic, anxiety, and dissociation questionaires before the infusion and after the CCK-4 stimulus. Furthermore, the stress- sensitive hormones adrenocorticotropic hormone (ACTH), cortisol, and prolactin were measured. CNP pretreatment enhanced the anxiogenic and prodissociative effects of CCK-4 and significantly augmented the ACTH surge after CCK-4. However, no effect of CNP was seen upon panic symptoms. Our preliminary data support a role of type-B natriuretic peptide receptors in anxiety modulation in normal man. (C) 2002 Elsevier Science Ltd. All rights reserve