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Journal Article

Intolerance to neuroleptics and susceptibility for malignant hyperthermia in a patient with proximal myotonic myopathy (PROMM) and schizophrenia

MPS-Authors

Schneider,  C
Max Planck Institute of Psychiatry, Max Planck Society;

Gil,  FP
Max Planck Institute of Psychiatry, Max Planck Society;

Schneider,  M
Max Planck Institute of Psychiatry, Max Planck Society;

Anetseder,  M
Max Planck Institute of Psychiatry, Max Planck Society;

Kress,  W
Max Planck Institute of Psychiatry, Max Planck Society;

Müller,  CR
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Schneider, C., Gil, F., Schneider, M., Anetseder, M., Kress, W., & Müller, C. (2002). Intolerance to neuroleptics and susceptibility for malignant hyperthermia in a patient with proximal myotonic myopathy (PROMM) and schizophrenia. Neuromuscular Disorders, 12(1), 31-35.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-A265-3
Abstract
We report a patient with proximal myotonic myopathy who was treated with neuroleptics because of exacerbating schizophrenia. Under therapy with fluanxol, the patient developed muscle stiffness and oculogyric cramps. Treatment with both amisulpride and olanzapine lead to markedly elevated serum creatine kinase levels. An in-vitro contracture test was positive for halothane. Thus, in patients with all kinds of multisystemic myotonic myopathies, a susceptibility for malignant hyperthermia and intolerance towards neuroleptics should be taken into account. (C) 2002 Elsevier Science B.V. All rights reserve