mPet-1, a mouse ETS-domain transcription factor, is expressed in central 
serotonergic neurons

Pfaar, H; von Holst, A; Weisenhorn, DMV; Brodski, C; Guimera, J; Wurst, W

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mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons

MPG-Autoren

Pfaar, H
Max Planck Institute of Psychiatry, Max Planck Society;

von Holst, A
Max Planck Institute of Psychiatry, Max Planck Society;

Weisenhorn, DMV
Max Planck Institute of Psychiatry, Max Planck Society;

Brodski, C
Max Planck Institute of Psychiatry, Max Planck Society;

Guimera, J
Max Planck Institute of Psychiatry, Max Planck Society;

Wurst, W
Max Planck Institute of Psychiatry, Max Planck Society;

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Zitation

Pfaar, H., von Holst, A., Weisenhorn, D., Brodski, C., Guimera, J., & Wurst, W. (2002). mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Development Genes and Evolution, 212(1), 43-46.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-000E-A255-9

Zusammenfassung

Here we describe the expression pattern of a previously unknown mouse gene mPet-1. The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to the nucleus. mPet-1 is a member of the winged helix transcription factor gene family like its rat homologue Pet-1 and the human homologue FEV. The start ATG of mPet-1 and the size of the predicted protein are identical to the human FEV. The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet-1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood. In these regions mPet-1 expression co- localizes precisely with the serotonin transporter (Sert), which it initially precedes. Interestingly, mPet-1 was not found in neurons transiently expressing Ser