Prolactin but not ACTH increases during sodium lactate-induced panic attacks

Otte, C; Kellner, M; Arlt, J; Jahn, H; Holsboer, F; Wiedemann, K

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Prolactin but not ACTH increases during sodium lactate-induced panic attacks

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Otte, C
Max Planck Institute of Psychiatry, Max Planck Society;

Kellner, M
Max Planck Institute of Psychiatry, Max Planck Society;

Arlt, J
Max Planck Institute of Psychiatry, Max Planck Society;

Jahn, H
Max Planck Institute of Psychiatry, Max Planck Society;

Holsboer, F
Max Planck Institute of Psychiatry, Max Planck Society;

Wiedemann, K
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Otte, C., Kellner, M., Arlt, J., Jahn, H., Holsboer, F., & Wiedemann, K. (2002). Prolactin but not ACTH increases during sodium lactate-induced panic attacks. Psychiatry Research, 109(2), 201-205.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-A233-6

Abstract

Paradoxically, the pituitary-adrenal axis is not activated during sodium lactate-induced panic. We measured the response of another stress-sensitive hormone, prolactin, to standard lactate and placebo infusion in a double-blind randomised design in eight patients with panic disorder and eight matched normal controls. Prolactin release was significantly elevated (P<0.05) in panickers compared with non-panickers, whereas ACTH secretion was not activated at all. This differential stress response needs further investigation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserve