The effects of the neuroactive steroid 3α , 5α- THDOC on sleep in the rat

Müller-Preuss, P; Rupprecht, R; Lancel, M

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The effects of the neuroactive steroid 3α , 5α- THDOC on sleep in the rat

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Müller-Preuss, P
Max Planck Institute of Psychiatry, Max Planck Society;

Rupprecht, R
Max Planck Institute of Psychiatry, Max Planck Society;

Lancel, M
Max Planck Institute of Psychiatry, Max Planck Society;

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Müller-Preuss, P., Rupprecht, R., & Lancel, M. (2002). The effects of the neuroactive steroid 3α, 5α- THDOC on sleep in the rat. NeuroReport, 13(4), 487-490.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-A22F-1

Abstract

This vehicle-controlled study assessed the sleep effects of the naturally occurring neuroactive steroid 3alpha 5alpha- tetrahydrodeoxycorticosterone (3alpha,5alpha-THDOC; 7.5 and 15 mg/kg), administered i.p. to rats, and compared them with those of another neuroactive steroid allopregnanolone (IS mg/kg). 3alpha,5alpha-THDOC shortened sleep latency, selectively promoted pre-REMS (a transitional state between non-REMS and REMS) and lengthened the non-REMS episodes dose-dependently. Spectral analysis of the EEG within nonREMS found significant attenuations of low-frequency activity and elevations in the spindle and higher frequency bands. The effects of 3alpha,5alpha-THDOC closely match those of allopregnanolone, indicating a common mechanism of action. Since the sleep changes produced by these steroids resemble the sleep profile of benzodiazepine hypnotics, they are probably caused by a positive allosteric modulation of GABA(A) receptor functi