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Journal Article

Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: Correlations with gadolinium-enhancing lesions and ventricular volume

MPS-Authors

Schumann,  EM
Max Planck Institute of Psychiatry, Max Planck Society;

Kumpfel,  T
Max Planck Institute of Psychiatry, Max Planck Society;

Then Bergh,  F
Max Planck Institute of Psychiatry, Max Planck Society;

Trenkwalder,  C
Max Planck Institute of Psychiatry, Max Planck Society;

Holsboer,  F
Max Planck Institute of Psychiatry, Max Planck Society;

Auer,  DP
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Schumann, E., Kumpfel, T., Then Bergh, F., Trenkwalder, C., Holsboer, F., & Auer, D. (2002). Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: Correlations with gadolinium-enhancing lesions and ventricular volume. Annals of Neurology, 51(6), 763-767.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-A1CB-7
Abstract
The known interaction between the immune system and the hypothalamic-pituitary-adrenal axis led us to explore the interrelation between magnetic resonance imaging findings and the hypothalamic-pituitary-adrenal axis activity in 53 multiple sclerosis patients. The cortisol release induced by the dexamethasone-corticotropin-releasing hormone test was negatively associated with the presence and number of gadolinium-enhancing lesions and positively associated with ventricular size. This finding suggests a protective effect of the hypothalamic-pituitary-adrenal drive on acute lesional inflammation in multiple sclerosis, probably by limiting immune overshoot. In contrast, the nature of the correlation between hypothalamic-pituitary-adrenal hyperdrive and brain atrophy remains to be determine