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Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients

MPG-Autoren

Bahner,  D
Max Planck Institute of Psychiatry, Max Planck Society;

Klucke,  C
Max Planck Institute of Psychiatry, Max Planck Society;

Kitze,  B
Max Planck Institute of Psychiatry, Max Planck Society;

Elitok,  E
Max Planck Institute of Psychiatry, Max Planck Society;

Bogumil,  T
Max Planck Institute of Psychiatry, Max Planck Society;

Dressel,  A
Max Planck Institute of Psychiatry, Max Planck Society;

Tumani,  H
Max Planck Institute of Psychiatry, Max Planck Society;

Weber,  F
Max Planck Institute of Psychiatry, Max Planck Society;

Poser,  S
Max Planck Institute of Psychiatry, Max Planck Society;

Bitsch,  A-
Max Planck Institute of Psychiatry, Max Planck Society;

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Zitation

Bahner, D., Klucke, C., Kitze, B., Elitok, E., Bogumil, T., Dressel, A., et al. (2002). Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients. Neuroscience Letters, 326(2), 125-128.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000E-A1C1-C
Zusammenfassung
Serum levels of interleukin-12 heterodimer (IL-12p70) and its homodimeric subunit (IL-12p40) were analyzed by enzyme-linked immunosorbent assay in 18 patients with primary progressive multiple sclerosis (MS) during 3 months before and 3 months under treatment with interferon-beta-1b (IFNbeta-1b, Betaferon(TM), eight million units (MIU) every other day subcutaneously). Median IL-12p40 levels in MS patients before treatment (66.5 and 63.9 pg/ml) were not elevated compared to 18 healthy controls. IL-12p40 significantly increased during treatment (P < 0.0001, median 105.3 pg/ml after 1 month and 95.3 pg/ml after 3 months). Detectable serum levels of IL-12p70 before therapy were only found in one patient. IL-12p70 did not increase during treatment. These data show that immunological processes may also play a role in primary progressive MS and that IFNbeta-1b has an immunomodulating effect in this particular MS subtype. (C) 2002 Published by Elsevier Science Ireland Ltd