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Journal Article

Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion

MPS-Authors

Reichenberg,  A
Max Planck Institute of Psychiatry, Max Planck Society;

Kraus,  T
Max Planck Institute of Psychiatry, Max Planck Society;

Haack,  M
Max Planck Institute of Psychiatry, Max Planck Society;

Schuld,  A
Max Planck Institute of Psychiatry, Max Planck Society;

Pollmächer,  T
Max Planck Institute of Psychiatry, Max Planck Society;

Yirmiya,  R
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Reichenberg, A., Kraus, T., Haack, M., Schuld, A., Pollmächer, T., & Yirmiya, R. (2002). Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion. Psychoneuroendocrinology, 27(8), 945-956.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-A01B-C
Abstract
This study examined the effects of endotoxin administration on food and water consumption in humans, and the associations between these changes and endotoxin-induced secretion of cytokines, cortisol, and fever. Twenty healthy male volunteers received an i.v. injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in two experimental sessions. Blood samples were collected hourly, and rectal temperature was monitored continuously. Food consumption was significantly reduced at 0-4 h and significantly elevated at 4-5 h after the endotoxin injection. Endotoxin administration had no significant effect on water consumption. Endotoxin-induced secretion of TNF-alpha and IL-6 was positively associated with the decrease in food consumption (r = 0.61 and 0.68), and negatively associated with the rebound increase in food consumption (r = -0.53 and -0.45). Neither the febrile response, nor the secretion of cortisol was associated with the changes in food consumption. These results suggest that TNF- alpha and IL-6 are involved in endotoxin-induced anorexia in humans. (C) 2002 Elsevier Science Ltd. All rights reserve