English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Novel Caspase-Suicide Proteins for Tamoxifen-Inducible Apoptosis

MPS-Authors
/persons/resource/persons80599

Wurst,  W.
Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Chu, Y. Y., Senghaas, N., Köster, R. W., Wurst, W., & Kühn, R. (2008). Novel Caspase-Suicide Proteins for Tamoxifen-Inducible Apoptosis. Genesis, 46(10), 530-536.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-93BF-3
Abstract
Taking advantage of a mutant estrogen receptor ligand binding domain (ER T), we developed novel Caspase fusion proteins for inducible apoptosis. We show that Caspase-ERT2 fusion proteins become specifically activated by the synthetic ligand 4-OH-tamoxifen and rapidly induce apoptotic cell death in human, murine, and zebrafish cells. This novel tool for targeted cell ablation greatly facilitates the generation of disease models as well as developmental and regeneration studies in model organisms. genesis 46:530-536, 2008. (C) 2008 Wiley-Liss, Inc.