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Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons80450

Müller-Myhsok,  B.
AG Müller-Myhsok, Bertram, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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Zitation

Ludwig, K. U., Roeske, D., Schumacher, J., Schulte-Körne, G., König, I. R., Warnke, A., et al. (2008). Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. Journal of Neural Transmission, 115(11), 1587-1589.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000E-939F-B
Zusammenfassung
The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.