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Gene Expression Studies in Major Depression

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons80438

Mehta,  D.
AG Binder, Elisabeth, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80440

Menke,  A.
AG Binder, Elisabeth, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80272

Binder,  E. B.
AG Binder, Elisabeth, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Mehta, D., Menke, A., & Binder, E. B. (2010). Gene Expression Studies in Major Depression. Current Psychiatry Reports, 12(2), 135-144.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-9090-3
Abstract
The dramatic technical advances in methods to measure gene expression on a genome-wide level thus far have not been paralleled by breakthrough discoveries in psychiatric disorders-including major depression (MD)-using these hypothesis-free approaches. In this review, we first describe the methodologic advances made in gene expression analysis, from quantitative polymerase chain reaction to next-generation sequencing. We then discuss issues in gene expression experiments specific to MD, ranging from the choice of target tissues to the characterization of the case group. We provide a synopsis of the gene expression studies published thus far for MD, with a focus on studies using mRNA microarray methods. Finally, we discuss possible new strategies for the gene expression studies in MD that circumvent some of the addressed issues.