de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Increased anxiety-related behaviour in Hint1 knockout mice

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons80420

Lebar,  M.
AG Turck, Christoph, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80372

Holsboer,  F.
Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80561

Turck,  C. W.
AG Turck, Christoph, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80557

Touma,  C.
AG Touma, Chadi, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Varadarajulu, J., Lebar, M., Krishnamoorthy, G., Habelt, S., Lu, J., Weinstein, I. B., et al. (2011). Increased anxiety-related behaviour in Hint1 knockout mice. Behavioural Brain Research, 220(2), 305-311.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000E-8E5E-2
Zusammenfassung
Several reports have implicated a role for the histidine triad nucleotide-binding protein-1 (Hint1) in psychiatric disorders. We have studied the emotional behaviour of male Hint1 knockout (Hint1 KO) mice in a battery of tests and performed biochemical analyses on brain tissue. The behavioural analysis revealed that Hint1 KO mice exhibit an increased emotionality phenotype compared to wildtype (WT) mice, while no significant differences in locomotion or general exploratory activity were noted. In the elevated plus-maze (EPM) test, the Hint1 KO animals entered the open arms of the apparatus less often than WT littermates. Similarly, in the dark-light box test, Hint1 KO mice spent less time in the lit compartment and the number of entries were reduced, which further confirmed an increased anxiety-related behaviour. Moreover, the Hint1 KO animals showed significantly more struggling and less floating behaviour in the forced swim test (FST), indicating an increased emotional arousal in aversive situations. Hint1 is known as a protein kinase C (PKC) interacting protein. Western blot analysis showed that PKC gamma expression was elevated in Hint1 KO compared to WT mice. Interestingly, PKC-gamma mRNA levels of the two groups did not show a significant difference, implying a post-transcriptional PKC-gamma regulation. In addition, PKC enzymatic activity was increased in Hint1 KO compared to WT mice. In summary, our results indicate a role for Hint1 and PKC gamma in modulating anxiety-related and stress-coping behaviour in mice. (C) 2011 Elsevier B.V. All rights reserved.