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Journal Article

Feeble awake effects of plasminogen activator inhibitor type-1 in mice

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons80499

Romanowski,  C. P. N.
AG Kimura, Mayumi, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80382

Jakubcakova,  V.
AG Kimura, Mayumi, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80324

Flachskamm,  C.
AG Kimura, Mayumi, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons80397

Kimura,  M.
AG Kimura, Mayumi, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Sakakibara, H., Romanowski, C. P. N., Jakubcakova, V., Flachskamm, C., Shimoi, K., & Kimura, M. (2011). Feeble awake effects of plasminogen activator inhibitor type-1 in mice. Behavioural Brain Research, 220(2), 354-357.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-8E5C-6
Abstract
Plasminogen activator inhibitor-type 1 (PAI-1) is involved in the fibrinolytic system and shows its increased levels in diseases, e.g., obesity and sleep apnea syndrome. The aim of the study is to investigate whether PAI-1 affects sleep-wake patterns in mice. When recombinant mouse PAI-1 was administered intraperitoneally, only rapid but short increases in time spent awake were observed after 20 or 100 mu g/kg, although its plasma concentration was kept high for an hour. The results suggest that PAI-1 may serve its role rather as a marker than an initiator of disturbed sleep. (C) 2011 Elsevier B.V. All rights reserved.