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Minimal systems to study membrane-cytoskeleton interactions

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons79158

Vogel,  Sven K.
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78689

Schwille,  Petra
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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Vogel, S. K., & Schwille, P. (2012). Minimal systems to study membrane-cytoskeleton interactions. Current Opinion in Biotechnology, 23(5), 758-765. doi:org/10.1016/j.copbio.2012.03.012.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-7D5F-9
Abstract
In the context of minimal systems design, there are two areas in which the reductionist approach has been particularly successful: studies of molecular motors on cytoskeletal filaments, and of protein-lipid interactions in model membranes. However, a minimal cortex, that is, the interface between membrane and cytoskeleton, has just begun to be functionally reconstituted. A key property of living cells is their ability to change their shape in response to extracellular and intracellular stimuli. Although studied in live cells since decades, the mutual dependence between cytoskeleton and membrane dynamics in these large-scale transformations is still poorly understood. Here we report on inspiring recent in vitro work in this direction, and the promises it holds for a better understanding of key cellular processes.