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A structure-based model of RIG-I activation

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons79135

Kowalinski,  Eva
Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Kolakofsky, D., Kowalinski, E., & Cusack, S. (2012). A structure-based model of RIG-I activation. RNA-A PUBLICATION OF THE RNA SOCIETY, 18(12), 2118-2127. doi:10.1261/rna.035949.112.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000E-7A15-9
Abstract
A series of high-resolution crystal structures of RIG-I and RIG-I: dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.