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Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information.

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50127

Costa,  Ivan G.
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50523

Schliep,  Alexander
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information. Berlin/Heidelberg: Springer.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8CED-A
Abstract
We propose a method for global validation of gene clusterings. The method selects a set of informative and non-redundant GO terms through an exploration of the Gene Ontology structure guided by mutual information. Our approach yields a global assessment of the clustering quality, and a higher level interpretation for the clusters, as it relates GO terms with specific clusters. We show that in two gene expression data sets our method offers an improvement over previous approaches.