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Gene for integrin-associated protein (IAP, CD47): physical mapping, genomic structure, and expression studies in skeletal muscle.

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50580

Sudbrak,  Ralf
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Schickel, J., Stahn, K., Zimmer, K.-P., Sudbrak, R., Størm, T. M., Dürst, M., et al. (2002). Gene for integrin-associated protein (IAP, CD47): physical mapping, genomic structure, and expression studies in skeletal muscle. Biochemistry and Cell Biology, 80(2), 169-176.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8CA8-4
Abstract
Integrin-associated protein (IAP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. Having physically mapped the IAP gene into a BAC/PAC contig covering approximately 1 Mb on human chromosome 3q13.1-q13.2, we determined the genomic organization of the gene, established its expression in skeletal muscle, and identified a novel splice variant. Our expression studies demonstrate expression of integrin- associated protein in the t-tubular system and the euchromatin of skeletal muscle cells where its function thus far is not known.