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Journal Article

Biogenesis of T Pili in Agrobacterium tumefaciens Requires Precise VirB2 Propilin Cleavage and Cyclization

MPS-Authors

Lanka,  Erich
Max Planck Society;

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Citation

Lai, E.-M., Eisenbrandt, R., Kalkum, M., Lanka, E., & Kado, C. I. (2002). Biogenesis of T Pili in Agrobacterium tumefaciens Requires Precise VirB2 Propilin Cleavage and Cyclization. Journal of Bacteriology, 184(1), 327-330.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8C88-C
Abstract
VirB2 propilin is processed by the removal of a 47-amino-acid signal peptide to generate a 74-amino-acid peptide product in both Escherichia coli and Agrobacterium tumefaciens. The cleaved VirB2 protein is further cyclized to form the T pilin in A. tumefaciens but not in E. coli. Mutations in the signal peptidase cleavage sequence of VirB2 propilin cause the formation of aberrant T pilin and also severely attenuate virulence. No T pilus was observed in these mutants. The potential role of the exact VirB2 propilin cleavage and cyclization in T pilus biogenesis and virulence is discussed.