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Journal Article

Tying rings for sex

MPS-Authors

Lurz,  Rudi
Max Planck Society;

Lanka,  Erich
Max Planck Society;

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Citation

Kalkum, M., Eisenbrandt, R., Lurz, R., & Lanka, E. (2002). Tying rings for sex. Trends in Microbiology, 10(8), 382-387.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8BD0-3
Abstract
The primary component of the sex pilus encoded by IncP (RP4) and Ti plasmids has been identified as a circular pilin protein with a peptide bond between the amino and carboxyl terminus. Here, we review the key experiments that led to this discovery, and the present mechanistic model for pilin-precursor processing and the cyclization reaction. In addition, we discuss the implications for horizontal gene transfer in bacterial conjugation.