Reduced body growth and excessive incisor length in insertional mutants mapping 
to mouse Chromosome 13

Petznek, Helga; Kappler, Roland; Scherthan, Harry; Müller, Mathias; Brem, Gottfried; Aigner, Bernhard

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Reduced body growth and excessive incisor length in insertional mutants mapping to mouse Chromosome 13

MPS-Authors

/persons/resource/persons50515

Scherthan, Harry
Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Petznek, H., Kappler, R., Scherthan, H., Müller, M., Brem, G., & Aigner, B. (2002). Reduced body growth and excessive incisor length in insertional mutants mapping to mouse Chromosome 13. Mammalian Genome, 13(9), 504-509.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-8B95-7

Abstract

Phenotypic and molecular genetic examinations of a transgenic mouse line showing developmental defects caused by a recessive insertional mutation were carried out. The mutant phenotype is characterized by general retardation of postnatal body growth and by the appearance of increased incisor length in the upper and lower jaw. The mutation causing the aberrant phenotype was mapped to Chromosome 13, 40 cM. Examination of the expression of the candidate genes did not show any alterations. This mutant mouse line provides a reproducible model for the identification and examination of gene(s) involved in growth and in the craniofacial development, including that of the jaws and teeth.