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Beta-2 Adrenergic receptor gene variations and coping styles in twins

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50204

Hoehe,  Margret R.
Genetic Variation, Haplotypes, and Genetics of Complex Disease (Margret Hoehe), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50598

Timmermann,  Bernd
Sequencing, Max Planck Institute for Molecular Genetics, Max Planck Society;

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Zitation

Busjahn, A., Freier, K., Faulhaber, H.-D., Li, G.-H., Rosenthal, M., Jordan, J., et al. (2002). Beta-2 Adrenergic receptor gene variations and coping styles in twins. Biological Psychology, 61(1 - 2), 97-109.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-8B93-B
Zusammenfassung
We tested the hypothesis that the beta-2 adrenergic receptor (beta-2 AR) gene locus, with known effects on blood pressure regulation, is also involved in psychological coping styles. 166 pairs of monozygotic (MZ) and dizygotic (DZ) twins and DZ twin parents were investigated. We found common genetic variance for the coping factor Emotional Coping and blood pressure. Using three microsatellites we found linkage between the beta-2 AR gene locus and the coping factor Active Coping. Using allele-specific PCR of all the single nucleotide polymorphisms (SNPs) in the gene causing amino acid substitutions we identified associations between the +491 G/A SNP and various coping factors. We conclude that the beta-2 AR gene is relevant to coping. These preliminary findings suggest a molecular genetic underpinning of the relationship between psychological and physiological phenotypes important to cardiovascular risk.