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Steps toward mapping the human vasculature by phage display

MPG-Autoren

Cahill,  Dolores
Max Planck Society;

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Zitation

Arap, W., Kolonin, M. G., Trepel, M., Lahdenranta, J., Cardó-Vila, M., Giordano, R. J., et al. (2002). Steps toward mapping the human vasculature by phage display. Nature Medicine, 8(2), 121-127.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-8B7B-3
Zusammenfassung
The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand–receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.