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Journal Article

Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A-flavicollis in nature

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Schmidt,  Heiko A.
Max Planck Society;

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Citation

Klempa, B., Schmidt, H. A., Ulrich, R., Kaluz, S., Labuda, M., Meisel, H., et al. (2003). Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A-flavicollis in nature. Journal of Virology, 77(1), 804-809. doi:10.1128/JVI.77.1.804-809.2003.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8AFF-5
Abstract
Dobrava virus (DOBV) occurs in two different rodent species, Apodemus flavicollis (DOBV-Af) and A. agrarius (DOBV-Aa). We sequenced the S and M genomic segments from sympatric DOBV-Af and DOBV-Aa strains which fell into two distinct genetic lineages. Molecular phylogenetic analyses gave evidence for genetic reassortment between S and M segments of DOBV-Af and DOBV-Aa and indicated homologous recombination events in DOBV evolution. DOBV-Af and DOBV-Aa are distinct but also subject to genetic exchanges that affect their evolutionary trajectories.