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Journal Article

Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50580

Sudbrak,  Ralf
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50488

Reinhardt,  Richard
High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50200

Hennig,  Steffen
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50409

Lehrach,  Hans
Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Sudbrak, R., Reinhardt, R., Hennig, S., Lehrach, H., Gunther, E., & Walter, L. (2003). Comparative and evolutionary analysis of the rhesus macaque extended MHC class II region. Immunogenetics, 54(10), 699-704. doi:10.1007/s00251-002-0515-z.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8AFB-D
Abstract
The sequence-based map of a part of the rhesus macaque major histocompatibility complex (MHC) extended class II region is presented. The sequenced region encompasses 67,401 bp and contains the SACM2L, RING1, FABGL and KE4 genes, as well as the HTATSF1-like and ZNF-like pseudogenes. Similar to human, but different from rat and mouse, no class I genes are found in the SACM2L-RING1 interval. The rhesus macaque extended MHC class II region shows a high degree of conservation of exonic as well as intronic and intergenic sequences compared with the respective human region. It is concluded that this particular genomic organization of the extended class II region--i.e., the absence of class I genes and the presence of the HTATSF1-like and ZNF-like pseudogenes--can be traced back to a common ancestor of humans and rhesus macaques about 23 million years ago.