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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons50204

Hoehe,  Margret R.
Genetic Variation, Haplotypes, and Genetics of Complex Disease (Margret Hoehe), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Franke, P., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., et al. (2003). Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence. European Psychiatry, 18(1), 18-22. doi:10.1016/S0924-9338(02)00005-6.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8AB8-1
Abstract
Objective: In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human -opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods: In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results: For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. – Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.