de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons50204

Hoehe,  Margret R.
Genetic Variation, Haplotypes, and Genetics of Complex Disease (Margret Hoehe), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Franke, P., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., et al. (2003). Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence. European Psychiatry, 18(1), 18-22. doi:10.1016/S0924-9338(02)00005-6.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-8AB8-1
Zusammenfassung
Objective: In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human -opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods: In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results: For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. – Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.