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Journal Article

Increase of functional diversity by alternative splicing

MPS-Authors

Koch,  Ina
Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons50613

Vingron,  Martin
Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Kriventseva, E. V., Koch, I., Apweiler, R., Vingron, M., Bork, P., Gelfand, M. S., et al. (2003). Increase of functional diversity by alternative splicing. Trends in Genetics, 19(3), 124-128. doi:10.1016/S0168-9525(03)00023-4.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-8A9C-1
Abstract
A large-scale analysis of protein isoforms arising from alternative splicing shows that alternative splicing tends to insert or delete complete protein domains more frequently than expected by chance, whereas disruption of domains and other structural modules is less frequent. If domain regions are disrupted, the functional effect, as predicted from 3D structure, is frequently equivalent to removal of the entire domain. Also, short alternative splicing events within domains, which might preserve folded structure, target functional residues more frequently than expected. Thus, it seems that positive selection has had a major role in the evolution of alternative splicing.